Fenton
Preparation and characterization of new non-symmetric ligands and their respective metal complexes related to the development of new anti-tumor agents, radiopharmaceuticals, and functional models of metalloenzymes with possible applications in biotechnology, biomarkers for diagnostic exams, and therapies.
Professor Dr. Adailton João Bortolluzi
Bioinspired Metallohydrolases and Catecholases
The research is related to the synthesis and complete characterization of coordination compounds, covalently anchored to non-coordinating groups such as protonated diamines, which are used as the supporting skeleton of biomimetic systems. Synthetic chemical modifications of the diamines, with the introduction of organic functional groups such as naphthalene, anthracene, pyrene, etc., allow us to study the secondary effects (second coordination sphere) of non-coordinating groups on the catalytic activities of the compounds’ hydrolase and catecholase. Finally, the anchoring of molecular residues capable of specifically and efficiently intercalating DNA base pairs (A-T and G-C) allows us to evaluate the compounds as potential new anti-tumor agents.
Professor Dr. Ademir Neves
Professora Dra. Rosely Aparecida Peralta
Photochemistry of organometallic compounds
The development of metal-carbonyl complexes as carbon monoxide-releasing molecules has been a focus of study. The use of light to initiate the release of carbon monoxide (PhotoCORM) from the carrier molecule using different coligands has been explored for its biological potential in the context of treating vascular diseases and antibacterial chemotherapy. In addition to optimizing the CO release parameters, such as excitation wavelength and release kinetics, which are controlled by appropriate combinations of metal-coligand, our research focus is increasingly aimed at improving the bioavailability of our CO-releasing molecules, which involves systematic variation of the external ligand periphery.
Professora Dra. Rosely Aparecida Peralta
Synthesis of inorganic and hybrid nanostructured materials, Sol-gel method, and Heterogeneous photocatalysis
Focused on the guiding theme of “Materials Chemistry for Sustainability,” this research line aims to develop chemical synthesis and processing routes for nanostructured materials (nanoparticles, mesoporous materials, films, and aerogels) that are either inorganic or organic-inorganic hybrids for applications in topics of relevance to Sustainable Development, including:
- Supported photocatalysts for environmental remediation, water treatment, and energy generation
- Waste reuse for advanced material production
- Nanoporous adsorbents for the recovery of metals and rare earth elements
Professor Dr. Elias Paiva Ferreira Neto
Agradecimentos – Apoios Financeiros
